CHI-Sponsored Research

Parisier SC, Fayad JN, Kimmelman CP. Microtia, canal atresia, and middle ear anomalies. In JB Snow Jr, JJ Ballenger, eds., Ballenger's Otorhinolaryngology Head and Neck Surgery, 16th ed., chapter 42, pp. 997-1008. Hamilton, Ontario: BC Decker, 2003.

Fayad JN, Wanna GB, Micheletto JN, Parisier SC. "Facial nerve paralysis following cochlear implant surgery." Laryngoscope. 113: 1344-1346, August 2003.

Fayad JN, Tabaee A, Micheletto JN, Parisier SC. "Cochlear implantation in children with otitis media." Laryngoscope. 113: 1224-1227, July 2003.

Parisier SC. "Cochlear implants: growing pains." Laryngoscope. 113:1470-1472, September 2003.

The Children’s Hearing Institute has provided a $30,000 grant to New York Medical College in support of a clinical research pilot study entitled “Cellular Biology of Cholesteatoma Research.” This study is being conducted through the collaboration of the otologists at The New York Eye & Ear Infirmary (Drs. Alexiades, Arigo, Kim, Linstrom, Parisier) and the lab of Renato Rozental, MD at New York Medical College. Principal Investigator George Alexiades, MD describes the study: “Cholesteatoma, a benign skin cyst in the middle ear, is a slowly erosive lesion that eats away at the bones of hearing and causes frequent infections. The behavior of cholesteatoma is quite variable, where it can be very aggressive in some patients, and in others can be quiescent for years, then abruptly become symptomatic. The histologic analysis of the skin reveals normal skin structure and cannot distinguish the aggressive from the quiescent cholesteatomas. As a result, we are looking into the cellular biology of cholesteatoma to see if we can identify what causes this tissue to behave aggressively. By examining the RNA of cholesteatoma samples and comparing it to normal skin samples, we are able to identify which genes are up- or down-regulated which may give insight to certain factors that influence the behavior of the cholesteatoma. After identifying these genes and the proteins which they regulate, we hope to then control their expression and ultimately control the behavior of the cholesteatoma. We are currently in the preliminary studies of identifying those genes which are differently expressed in cholesteatoma.”